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In Vivo Gene Editing

gene editing

andriano & cz from Getty Images

Several companies are experimenting on human subjects to develop gene editing that is performed inside the body. Such therapies differ from a recently approved treatment for sickle-cell anemia that removes bone marrow from the body before editing the genetic material and reintroducing it into the patient.

Intellia Therapeutics and Regeneron Pharmaceuticals are in clinical trials to use gene editing to knock out a gene that causes fibrous protein clumps, which can accumulate in organs and nerves, increasing the risk of heart failure and other serious complications. Verve Therapeutics is enrolling patients to test a gene-editing protocol designed to reverse the effects of a genetic disease that leads to severely elevated cholesterol and increased risk of early-onset cardiovascular disease. One caveat: These therapies carry the risk of editing unrelated genes.


This article appears in the July 2024 issue of Natural Awakenings.


In-Print National Content Global and Health Briefs Health Brief July 2024
Tick Talk

Spring officially sprung on March 21. We have turned our clocks ahead. We are looking forward to warm winds, sunny skies and the smell of fresh cut grass. The daffodils and tulips have recently bloomed and we are just starting with the yard work that comes with the warmer weather.  Sadly, another season has started ramping up.  Tick season.

•             The best form of protection is prevention. Educating oneself about tick activity and how our behaviors overlap with tick habitats is the first step.

•             According to the NJ DOH, in 2022 Hunterdon County led the state with a Lyme disease incidence rate of 426 cases per 100,000 people. The fact is ticks spend approximately 90% of their lives not on a host but aggressively searching for one, molting to their next stage or over-wintering. This is why a tick remediation program should be implemented on school grounds where NJ DOH deems high risk for tick exposure and subsequent attachment to human hosts.

•             Governor Murphy has signed a bill that mandates tick education in NJ public schools. See this for the details.  Tick education must now be incorporated into K-12 school curriculum. See link:

https://www.nj.gov/education/broadcasts/2023/sept/27/TicksandTick-BorneIllnessEducation.pdf

•             May is a great month to remind the public that tick activity is in full swing. In New Jersey, there are many tickborne diseases that affect residents, including Anaplasmosis, Babesiosis, Ehrlichiosis, Lyme disease, Powassan, and Spotted Fever Group Rickettsiosis.

•             For years, the focus has mainly been about protecting ourselves from Lyme disease. But other tick-borne diseases are on the rise in Central Jersey. An increase of incidence of Babesia and Anaplasma are sidelining people too. These two pathogens are scary because they effect our blood cells. Babesia affects the red blood cells and Anaplasma effects the white blood cells.

•             Ticks can be infected with more than one pathogen. When you contract Lyme it is possible to contract more than just that one disease. This is called a co-infection. It is super important to pay attention to your symptoms. See link.

https://twp.freehold.nj.us/480/Disease-Co-Infection

A good resource from the State:

https://www.nj.gov/health/cd/topics/tickborne.shtml

 

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