Research from Brazil’s Universidade Nove de Julho has confirmed that pulsed lasers and LED therapy applied during treatment can significantly reduce knee pain. The 86 patients that participated in the study were divided into two groups; one received 12 treatments using super-pulsed red laser and infrared LED phototherapy and the control (placebo) group received 12 treatments using non-therapeutic phototherapy instruments. The patients given therapeutic phototherapy reported feeling significantly less pain, beginning with and continuing after the 10th treatment through a one-month follow-up visit, and showed improved quality of life compared with a placebo group.